ORBIMED ADVISORS LLC

Most recent update: Sept. 30, 2017

CompanyShares/WarrantsValue ($000)
Alexion Pharmaceuticals3,645,486511,425
Biogen Idec Inc.1,630,000510,386
Celgene Corporation3,351,977488,785
Boston Scientific Corporation13,397,000390,790
Merck & Company5,487,000351,333
Vertex Pharmaceuticals Incorporated2,074,302315,377
Puma Exploration, Inc.2,425,735290,482
Eli Lilly and Company3,075,000263,036
Regeneron Pharmaceuticals572,770256,097
Wright Medical Group17,659,322244,944
CIGNA High Income Shares1,266,100236,685
Amgen Inc.1,253,100233,640
All Marketing Solutions Inc.3,638,900233,617
Aetna Inc.1,396,500222,057
Clovis Oncology2,388,670196,826
Incyte Corporation1,676,000195,656
Anthem United, Inc.927,618176,136
AbbVie Inc1,965,000174,610
Array BioPharma Inc.14,182,900174,450
Loxo Oncology, Inc.1,728,000159,183
Gilead Sciences1,928,000156,207
Edwards Lifesciences Corporation1,390,700152,017
Johnson & Johnson1,124,400146,183
Allergan461,790141,643
Immunomedics9,996,816139,755
BeiGene, Ltd.1,313,788135,925
Alnylam Pharmaceuticals1,084,800127,453
Ascendis Pharma3,367,315122,065
Audentes Therapeutics, Inc.4,129,638115,671
Mylan Inc.3,601,100112,967
Jazz Pharmaceuticals plc749,200109,571
Select Medical Holdings Corporation5,578,500107,107
Thermo Fisher Scientific Inc534,200101,071
Juno Therapeutics, Inc.2,041,60891,587
Ironwood Gold Corp.5,759,20090,823
Pfizer2,458,80087,779
Corvus Pharmaceuticals, Inc.5,379,34985,747
Illumina398,50079,381
Shire plc499,90876,556
Magellan Health Services882,60076,168
United States Cellular Corporation380,00074,423
GLOBAL HEALTHCARE REIT, INC.2,393,63574,322
Universal Health Services669,00074,219
BioMarin Pharmaceutical Inc.1,743,90070,395
Aerie Pharmaceuticals Inc.1,438,18269,896
Investec Ltd.879,00068,360
bluebird bio, Inc.481,94666,195
Intellia Therapeutics, Inc.2,662,18066,155
Bristol-Myers Squibb Company1,024,70065,314
Stryker Corporation421,00059,790
Intuitive Surgical56,40058,988
Achillion Pharmaceuticals13,062,90058,652
Insmed1,875,01658,519
GW Pharmaceuticals561,07156,943
Integrated Research Ltd.1,090,91055,069
Mallinckrodt Plc1,472,70055,035
INSYS Therapeutics, Inc.6,171,44054,802
ViewRay, Inc.9,458,56754,481
Kala Pharmaceuticals, Inc.2,375,27954,251
Galapagos523,79053,296
Iovance Biotherapeutics6,425,62649,799
NEVRO CORP494,90044,977
eHealth1,834,70043,831
Radius Bancorp Inc.1,122,80043,284
Pieris Pharmaceuticals, Inc.7,259,62041,815
ImmunoGen5,450,58141,697
Synergy Pharmaceuticals13,621,44339,502
Momenta Pharmaceuticals2,109,06839,018
Spark Therapeutics430,01638,340
Dermira, Inc.1,418,87338,310
Alpine 4 Technologies Ltd.3,298,51638,263
SELECTA BIOSCIENCES INC1,842,79733,631
Dimension Therapeutics, Inc.5,397,69832,386
Nabriva Therapeutics3,919,60032,102
GLAUKOS Corp836,50027,605
Intercept Pharmaceuticals386,38022,425
DBV Technologies512,90021,767
Natera, Inc.1,576,19020,317
Envision Healthcare Holdings, Inc.440,70019,809
Sinovac Biotech2,667,50018,806
Zaio Corp.658,16017,770
Neurocrine Biosciences284,84117,455
Vanda Pharmaceuticals Inc.967,85917,325
Xencor Inc747,24417,127
Fluidigm Corporation11,746,10016,190
CTI Industries Corporation5,000,00015,950
Novo Nordisk A/S330,00015,890
Adaptimmune Therapeutics PLC1,914,66015,681
HCA Holdings187,40014,915
Coherus BioSciences, Inc.1,079,70014,414
InVitae1,518,19714,226
SteadyMed Ltd.4,246,19614,225
Novus Robotics Inc.2,537,11013,218
NuVasive220,70012,240
Aegerion Pharmaceuticals15,000,00012,151
Argentium Resources, Inc.500,00011,305
Heron Resources Limited HRR650,00010,498
Verona Pharma Plc666,66610,233
NewLink Genetics Corporation881,2748,971
Alkermes plc145,0007,372
Aeglea BioTherapeutics, Inc.1,469,5247,244
Teva Pharmaceutical Industries Ltd.405,5007,137
Sarepta Therapeutics150,0006,804
CRISPR Therapeutics AG372,1916,651
Redhill Biopharma564,9006,107
Halozyme Therapeutics350,0006,080
Sierra Metals3,703,7045,741
Zimmer Holdings49,0005,737
INOTEK PHARMACEUTICALS CORP7,000,0005,547
Syndax Pharmaceuticals Inc437,0005,113
GLYCOMIMETICS INC337,5884,723
Seres Therapeutics, Inc.294,4584,723
MARINUS PHARMACEUTICALS INC567,6003,332
Infinity Pharmaceuticals2,207,2452,936
Valeant Pharmaceuticals International194,9002,793
Otonomy, Inc.644,0742,093
Orexigen Therapeutics5,210,0002,042
Xenon Pharmaceuticals Inc.634,8121,873
BioLineRx Ltd.1,038,6001,163
Affimed Therapeutics326,650735
Novelion Therapeutics100,000703
Xtant Medical Holdings, Inc.475,439343
Alimera Sciences250,000338
Roka BioScience, Inc.201,617147
Versartis, Inc.50,000123

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