ORBIMED ADVISORS LLC

Most recent update: March 31, 2017

CompanyShares/WarrantsValue ($000)
Alexion Pharmaceuticals3,760,986455,982
Biogen Idec Inc.1,436,900392,877
Celgene Corporation3,132,177389,737
Boston Scientific Corporation15,311,400380,795
Merck & Company5,714,900363,125
Wright Medical Group16,096,234296,745
Eli Lilly and Company3,330,200280,103
Incyte Corporation1,973,597263,811
Vertex Pharmaceuticals Incorporated2,169,200237,202
Amgen Inc.1,438,300235,982
All Marketing Solutions Inc.3,629,900191,913
Allergan565,590188,890
Pfizer5,406,100184,943
Edwards Lifesciences Corporation1,839,300173,023
Aetna Inc.1,312,400167,397
Shire plc897,451156,363
HCA Holdings1,745,000155,288
Humet-PBC North America, Inc.742,300153,018
Regeneron Pharmaceuticals378,170146,545
Anthem United, Inc.862,600142,657
AbbVie Inc2,080,000135,533
Array BioPharma Inc.14,182,900126,795
Ironwood Gold Corp.7,241,300123,537
Bristol-Myers Squibb Company2,211,000120,234
Centenera Mng Corp.1,655,700117,985
Intercept Pharmaceuticals1,037,000117,285
BioMarin Pharmaceutical Inc.2,274,100113,000
Corvus Pharmaceuticals, Inc.5,379,349111,729
Johnson & Johnson884,600110,177
Synergy Pharmaceuticals21,153,34398,575
THC Biomed International Ltd.5,352,00094,784
GLAUKOS Corp1,741,70089,349
Insmed4,810,90584,239
Puma Exploration, Inc.2,245,92583,548
Thermo Fisher Scientific Inc534,20082,053
Audentes Therapeutics, Inc.4,801,63881,820
ViewRay, Inc.9,458,56780,492
Ascendis Pharma2,717,31576,085
Magellan Health Services1,088,72775,177
Loxo Oncology, Inc.1,728,00072,714
Aerie Pharmaceuticals Inc.1,496,00067,844
Mallinckrodt Plc1,472,70065,638
INSYS Therapeutics, Inc.6,071,44063,811
Medtronic766,60061,757
GW Pharmaceuticals475,90057,555
Eagle Pharmaceuticals671,00055,653
Achillion Pharmaceuticals13,107,20055,181
Illumina321,90054,929
Gilead Sciences800,90054,397
Jazz Pharmaceuticals plc371,40053,901
NewLink Genetics Corporation2,191,70052,820
Mylan Inc.1,300,00050,687
Immunomedics31,232,10050,233
United States Cellular Corporation296,40048,613
Stryker Corporation316,30041,641
ACADIA Pharmaceuticals Inc.1,169,00040,190
GLOBAL HEALTHCARE REIT, INC.1,084,50039,964
Intuitive Surgical50,40038,630
Cooper Companies190,80038,139
Intellia Therapeutics, Inc.2,662,18037,510
Dermira, Inc.1,023,67334,917
BeiGene, Ltd.903,70033,084
Sarepta Therapeutics1,054,30031,207
Momenta Pharmaceuticals2,109,06828,156
Select Medical Holdings Corporation2,086,30027,852
Radius Bancorp Inc.704,10027,213
SELECTA BIOSCIENCES INC1,842,79726,389
bluebird bio, Inc.283,80025,797
Lion Biotechnologies, Inc.3,382,90025,203
Galapagos283,50024,435
ImmunoGen6,095,64723,590
Coherus BioSciences, Inc.1,084,40022,935
Otonomy, Inc.1,850,09422,664
eHealth1,820,00021,913
Nabriva Therapeutics1,677,94020,135
Xencor Inc840,23720,098
Neurocrine Biosciences441,34119,110
Pieris Pharmaceuticals, Inc.7,259,62018,875
SteadyMed Ltd.3,072,19617,819
Fluidigm Corporation11,746,10016,750
Sinovac Biotech2,667,50015,285
C.R. Bard58,00014,415
EXACT Sciences Corporation602,90014,240
Teva Pharmaceutical Industries Ltd.412,60013,240
Aegerion Pharmaceuticals15,000,00012,317
Natera, Inc.1,276,19011,320
Aeglea BioTherapeutics, Inc.1,469,52410,948
Adaptimmune Therapeutics PLC1,914,66010,550
Infinity Pharmaceuticals3,250,30010,498
Heron Resources Limited HRR650,0009,750
Dimension Therapeutics, Inc.5,397,6989,446
NuVasive123,5009,223
Alkermes plc145,0008,483
CRISPR Therapeutics AG372,1918,103
NEVRO CORP77,8007,290
TESARO47,2007,263
Syndax Pharmaceuticals Inc484,8006,651
Zimmer Holdings49,0005,983
Minerva704,3005,705
Sierra Metals3,703,7045,667
Redhill Biopharma564,9005,417
InVitae456,6665,051
Affimed Therapeutics2,018,9004,643
INOTEK PHARMACEUTICALS CORP7,000,0004,433
Sientra, Inc.522,2574,397
Alnylam Pharmaceuticals82,2004,213
Roka BioScience, Inc.893,4703,181
Orexigen Therapeutics5,210,0002,591
Xenon Pharmaceuticals Inc.634,8122,539
Clearside Biomedical, Inc.300,0002,382
Valeant Pharmaceuticals International194,9002,150
Amarin Corporation PLC350,0001,120
Novelion Therapeutics100,0001,074
MARINUS PHARMACEUTICALS INC567,6001,005
BioLineRx Ltd.1,038,600998
Vanda Pharmaceuticals Inc.50,200703
Alimera Sciences250,000350
Xtant Medical Holdings, Inc.475,439296

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