CCT

Statement of acquisition of beneficial ownership by individuals



STYLE="font: 10pt Times New Roman, Times, Serif">



















UNITE D
STATES






SECURITIES
AND EXCHANGE COMMISSION






Washington,
D.C. 20549
























SCHEDULE
13G






Under
the Securities Exchange Act of 1934






(Amendment
No.    )*























EQRx,
Inc.











(Name
of Issuer)









Common Stock par value $0.0001 per share











(Title
of Class of Securities)









26886C107











(CUSIP
Number)








December
31, 2021










(Date
of Event Which Requires Filing of This Statement)
















Check the appropriate box to designate the rule pursuant to which
this Schedule is filed:



☐

Rule 13d-1(b)



☐   Rule 13d-1(c)



☒   Rule 13d-1(d)




*
The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to
the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided
in a prior cover page.




The information required in the remainder of this cover page shall
not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”)
or otherwise subject to the liabilities of that section of the Act, but shall be subject to all other provisions of the Act (however,
see the Notes).























CUSIP
No.  26886C107


13G


Page
2 of 16 Pages










































1





NAMES
OF REPORTING PERSON(S)









ARCH Venture Fund X, L.P.








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









Delaware















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER









36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)









7.5%










12





TYPE
OF REPORTING PERSON









PN

















































CUSIP
No.  26886C107


13G


Page
3 of 16 Pages












































1





NAMES
OF REPORTING PERSON(S)









ARCH Venture Fund X Overage, L.P.








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









Delaware















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER









36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)










7.5%










12





TYPE
OF REPORTING PERSON









PN















































CUSIP
No.  26886C107


13G


Page
4 of 16 Pages












































1





NAMES
OF REPORTING PERSON(S)









ARCH Venture Partners X, L.P.








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









Delaware















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER









36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)











7.5%










12





TYPE
OF REPORTING PERSON









PN













































CUSIP
No.  26886C107


13G


Page
5 of 16 Pages










































1





NAMES
OF REPORTING PERSON(S)









ARCH Venture Partners X Overage, L.P.








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









Delaware















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER









36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)









7.5%










12





TYPE
OF REPORTING PERSON









PN















































CUSIP
No.  26886C107


13G


Page
6 of 16 Pages










































1





NAMES
OF REPORTING PERSON(S)









ARCH Venture Partners X, LLC








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









Delaware















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER









36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)









7.5%










12





TYPE
OF REPORTING PERSON









OO


















































CUSIP
No.  26886C107


13G


Page
7 of 16 Pages














































1





NAMES
OF REPORTING PERSON(S)









Keith
Crandell








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









United States of America















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER









36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)











7.5%










12





TYPE
OF REPORTING PERSON









IN

















































CUSIP
No.  26886C107


13G


Page
8 of 16 Pages












































1





NAMES
OF REPORTING PERSON(S)









Kristina Burow








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









United
States of America















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER









36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)











7.5%










12





TYPE
OF REPORTING PERSON









IN

















































CUSIP
No.  26886C107


13G


Page
9 of 16 Pages












































1





NAMES
OF REPORTING PERSON(S)









Steven
Gillis








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









United States of America















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER










36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)









7.5%










12





TYPE
OF REPORTING PERSON









IN













































CUSIP
No.  26886C107


13G


Page
10 of 16 Pages












































1





NAMES
OF REPORTING PERSON(S)









Robert Nelsen








2





CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP





(a)

☐





(b)

☐



3





SEC
USE ONLY








4





CITIZENSHIP
OR PLACE OF ORGANIZATION









United States of America















































NUMBER
OF


SHARES


BENEFICIALLY


OWNED BY EACH


REPORTING


PERSON WITH







5





SOLE
VOTING POWER









0






6





SHARED
VOTING POWER










36,335,375






7





SOLE
DISPOSITIVE POWER









0






8





SHARED
DISPOSITIVE POWER









36,335,375













































9





AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON









36,335,375








10





CHECK
BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES





☐



11





PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW (9)











7.5%










12





TYPE
OF REPORTING PERSON









IN










































CUSIP
No.  26886C107


13G


Page
11 of 16 Pages





















Item
1(a).



Name
of Issuer:










EQRx, Inc. (the “Issuer”).


























Item
1(b).



Address
of Issuer's Principal Executive Offices:










50 Hampshire Street, Cambridge, MA 02139


























Item
2(a).



Name
of Person Filing:








ARCH Venture Fund X, L.P. (“AVF X”); ARCH Venture Partners
X, L.P. (“AVP X LP”); ARCH Venture Partners X, LLC (“AVP X LLC”); ARCH Venture Fund X Overage, L.P. (“AVF
X Overage”); ARCH Venture Partners X Overage, L.P. (“AVF X Overage GP”) (collectively, the “Reporting Entities”
and individually, each a “Reporting Entity”); and Keith Crandell (“Crandell”), Robert Nelsen (“Nelsen”),
Kristina Burow (“Burow”) and Steven Gillis (“Gillis) (collectively, the “Investment Committee” and individually,
each a “Committee Member”). The Reporting Entities and the Committee Members collectively are referred to as the “Reporting
Persons”.






























Item
2(b).



Address
of Principal Business Office or, if none, Residence:










8755 W. Higgins Avenue, Suite 1025, Chicago, IL 60631


























Item
2(c).



Citizenship:








Each of AVF X, AVF X LP, AVF X Overage and AVP X Overage GP, are limited
partnerships organized under the laws of the State of Delaware. AVP X LLC is a limited liability company organized under the laws of the
State of Delaware. Each Committee Member is a US citizen.


























Item
2(d).



Title
of Class of Securities.








Common stock, par value $0.0001 per share.






















Item
2(e).



CUSIP
Number.









26886C107






















Item
3.



If
this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing is a:







Not
Applicable.























CUSIP
No.


26886C107


13G


Page
12 of 16 Pages















Item
4.



Ownership:






















(a)


Amount beneficially owned:





AVF X is the record owner of 18,167,688 shares of Common Stock (the “AVF
X Shares”) as of December 31, 2021. AVP X LP, as the sole general partner of ARCH Venture Fund X, may be deemed to beneficially
own the AVF X Shares. AVF X Overage is the record owner of 18,167,687 shares of Common Stock (the “AVF X Overage Shares”;
combined with AVF X Shares, the “Record Shares”) as of December 31, 2021. AVF X Overage GP, as the sole general partner of
AVF X Overage, may be deemed to beneficially own the AVF X Overage Shares. AVP X LLC, as the sole general partner of AVP X LP and AVF
X Overage GP, may be deemed to beneficially own the Record Shares. As Committee Members of AVP X LLC, each Committee Member may also be
deemed to share the power to direct the disposition and vote of the Record Shares.


(b)


Percent of class:





See line 11 of the cover sheets. The percentages set forth on the cover
sheet for each Reporting Person is based upon 487,632,615 shares of common stock outstanding as of December 17, 2021 as reported on the
Issuer’s Form 424B3 as filed with the Securities and Exchange Commission on December 23, 2021.






(c)

Number of shares as to which such person has:

















































(i)


Sole power to vote or to direct the vote:





See line 5 of the cover sheets.






(ii)


Shared power to vote or to direct the vote:





See line 6 of the cover sheets.






(iii)


Sole power to dispose or to direct the disposition:





See line 7 of the cover sheets.






(iv)


Shared power to dispose or to direct the disposition:





See line 8 of the cover sheets.





Each Reporting Person disclaims beneficial ownership of such shares of
Common Stock except for the shares, if any, such Reporting Person holds of record.


















Item
5.



Ownership
of Five Percent or Less of a Class.




Not applicable.


















Item
6.



Ownership
of More than Five Percent on Behalf of Another Person.










Not applicable.



























Item
7.



Identification and Classification of the Subsidiary Which Acquired
the Security Being Reported on by the Parent Holding Company.







Not
applicable.


























Item
8.



Identification
and Classification of Members of the Group.







Not
applicable.
































Item
9.



Notice
of Dissolution of Group.







Not
applicable.


























Item
10.



Certifications.








Not
applicable.





















CUSIP
No.


26886C107


13G


Page
13 of 16 Pages













SIGNATURE






After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and correct.








Dated:    February
11, 2022




ARCH
VENTURE FUND X, L.P.








By:     
 ARCH Venture Partners X, L.P.




its General
Partner








By:       ARCH Venture Partners X, LLC




its General Partner








By:

*





Keith
Crandell




Managing
Director












ARCH VENTURE PARTNERS X, L.P.








By:     
 ARCH Venture Partners X, LLC




its General
Partner








By:

*





Keith Crandell




Managing Director














ARCH VENTURE PARTNERS X, LLC












By:

*





Keith Crandell




Managing Director



















ARCH VENTURE FUND X OVERAGE, L.P.





By:       ARCH
Venture Partners X Overage, L.P.



its General Partner





By:       ARCH Venture
Partners X, LLC



its General Partner






By:

*





Keith
Crandell




Managing Director









ARCH VENTURE PARTNERS X OVERAGE, L.P.





By:       ARCH
Venture Partners X, LLC



its General Partner






By:

*





Keith
Crandell




Managing Director



























CUSIP
No.


26886C107


13G


Page
14 of 16 Pages






















*





Keith Crandell













*





Robert Nelsen













*





Kristina Burow













*





Steven Gillis
















































* By:

/s/
Mark McDonnell





Mark
McDonnell as




Attorney-in-Fact











*       This Schedule 13D was executed by Mark McDonnell pursuant to Powers of
Attorney filed as Exhibit 24 and 24.1 to the Form 3 relating to the beneficial ownership of shares of Verve Therapeutics, Inc. by the
Reporting Persons filed with the Securities Exchange Commission on June 16, 2021 and incorporated herein in its entirety by reference.























CUSIP
No.  26886C107


13G


Page
15 of 16 Pages








Exhibit 1








AGREEMENT






Pursuant to Rule 13d-1-(k)(1) under the Securities Exchange Act of 1934,
the undersigned hereby agree that only one statement containing the information required by Schedule 13G need be filed with respect to
the ownership by each of the undersigned of shares of stock of EQRx, Inc.





This Agreement may be executed in any number of counterparts, each
of which shall be deemed an original.








Dated:   
February 11, 2022




ARCH
VENTURE FUND X, L.P.








By:     
 ARCH Venture Partners X, L.P.




its General
Partner








By:       ARCH Venture Partners X, LLC




its General Partner








By:

*





Keith
Crandell




Managing
Director












ARCH VENTURE PARTNERS X, L.P.








By:     
 ARCH Venture Partners X, LLC




its General
Partner








By:

*





Keith Crandell




Managing Director














ARCH VENTURE PARTNERS X, LLC












By:

*





Keith Crandell




Managing Director

















ARCH VENTURE FUND X OVERAGE, L.P.





By:       ARCH
Venture Partners X Overage, L.P.



its General Partner





By:       ARCH Venture
Partners X, LLC



its General Partner






By:

*





Keith
Crandell




Managing Director









ARCH VENTURE PARTNERS X OVERAGE, L.P.





By:       ARCH
Venture Partners X, LLC



its General Partner






By:

*





Keith
Crandell




Managing Director























CUSIP
No.


26886C107


13G


Page
16 of 16 Pages




































*





Keith Crandell













*





Robert Nelsen













*





Kristina Burow













*





Steven Gillis




















































* By:

/s/
Mark McDonnell





Mark
McDonnell as




Attorney-in-Fact











*            
This Agreement was executed by Mark McDonnell pursuant to Powers of Attorney
filed as Exhibit 24 and 24.1 to the Form 3 relating to the beneficial ownership of shares of Verve Therapeutics, Inc. by the Reporting
Persons filed with the Securities Exchange Commission on June 16, 2021 and incorporated herein in its entirety by reference.












































The above information was disclosed in a filing to the SEC. To see the filing, click here.

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